If you're at all a fan of the Alien series, then Prometheus will really piss you off. That, and it's a pretty terrible movie aside from that. Leaves nothing to the imagination, forcibly shoves its quasi-spiritual/philisophical plot down your throat all while treating the viewer as if they're retarded (I.e. by spelling out every last little stupid detail), and then posing/answering a slew of questions that no Alien fan gives a shit about, but completely ignoring any unanswered questions that they do have.
Scott kept insisting that it was NOT going to be an alien prequel, and I wish he had told the truth. It was entirely a prequel and entirely crap.
Just sayin'.