Have you seen the pro guitar controller? It's pretty much a 6 stringed guitar. And I hear they will be throwing simplified musical notation as well. If anything I'll end up sitting in front of the tv with my acoustic and no fail mode turned on. As of now all these games have served me was really intense finger training. If I can at least get the basics and chord training out of 3 I'll be extremely happy. And keyboard already translates key for key, I'll just have to brush up on musical theory and get me some pedals and I'll be set.
For the most part my lazy ass really doesn't like following onlines lessons, at least at the start. Rock Band makes that initial learning stage really fun, and then encourages me to move on and start creating my own stuff.