That's what I am afraid of.
Then don't be afraid of this game... because it's absolutely nothing like that.
The unlockables stay unlocked and you can't delete your high scores. That's it.
I'm picturing playing Super Mario Bros. World 1-1 on the NES, going through, killing a few Goombas and getting some coins... Then replaying it, but the goombas I killed the first time are still dead and the coins I got are gone. Know what I mean?
Not quite. Say Super Mario Bros. gives you a score when you beat the game, such as a high score. The next time you play the game it's going to be the same as the first time you played, but the high score is going to be saved from last time you played and you can try to beat it.
This. Also, think of Super Mario World - as you beat the various levels, they stay unlocked... including any secret paths you find. You can't start a new save file and beat the game "fresh", but you can re-play the levels as often as you want.
This particular Resident Evil game is different from the others because it's not really very story-based... it's like an old arcade game where the purpose of playing is to get a high score, then to get a better one.